Q.

When a cell has a stalled DNA replication fork, which checkpoint should be predominantly activated   [2016]

1 G1/S  
2 G2/S  
3 M  
4 Both G2/M and M  

Ans.

(2)

If cell has stalled DNA replication fork, it implies that it has crossed C G1or G1 cyclin cell cycle check point and has entered S-phase of cell cycle, where it is preparing for chromosome replication. Afterwards it will enter G2 phase and will soon approach second check point called mitotic cyclin (CM) which lies between G2 and M-phase.