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Solution


Q.

Osteoporosis, an age-related disease of skeletal system, may occur due to                  [2016]
1 immune disorder affecting neuromuscular junction leading to fatigue  
2 high concentration of Ca++ and Na+  
3 decreased level of estrogen  
4 accumulation of uric acid leading to inflammation of joints  

Ans.

(3)

Osteoporosis is reduction in bone mineral density, resulting in bones that are brittle and liable to fracture. Infection, injury and synovitis can cause localised osteoporosis of adjacent bone. Generalised osteoporosis is common in the elderly and in women after menopause. After menopause the estrogen level in blood plasma are much reduced. Estrogen helps to regulate bone cells called osteoclasts which are responsible for building new bone. When estrogen level drop fewer osteoclasts are produced resulting in osteoporosis.