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Solution


Q.

Melonate inhibits the growth of pathogenic bacteria by inhibiting the activity of               [2023]
1 Lipase  
2 Dinitrogenase  
3 Succinic dehydrogenase  
4 Amylase  

Ans.

(3)

In competitive inhibition, the inhibitor closely resembles the real substrate in its molecular structure and inhibits the activity of the enzyme. Due to its close structural similarity with the substrate, the inhibitor competes with substrate for the substrate binding site of enzymes. Consequently, the substrate cannot bind and as a result, the enzyme action declines.

Inhibition of succinic dehydrogenase by malonate is one example of competitive inhibition. Malonate closely resembles the substrate succinate in structure. Such competitive inhibitors are often used to inhibit the growth of pathogenic bacteria.