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Solution


Q.

Consider the following statements:       [2019]

(A) Coenzyme or metal ion that is tightly bound to enzyme protein is called a prosthetic group.
(B) A complete catalytically active enzyme with its bound prosthetic group is called an apoenzyme.

Select the correct option:
1

(A) is false but (B) is true.

 

2

Both (A) and (B) are true.

 

3

(A) is true but (B) is false.

 

4

Both (A) and (B) are false.

 


Ans.

(4)

Enzymes could be simple or conjugated (holoenzyme). Conjugated enzymes are formed of two parts – a protein part called apoenzyme and a non-protein part named co-factor. Co-factors are bound to the enzyme to make it catalytically active. There are three types of cofactors: prosthetic groups, co-enzymes, and metal ions. Prosthetic groups are organic compounds and are distinguished from other cofactors in which they are tightly bound to the apoenzyme. Co-enzymes are organic compounds but their association with the apoenzyme is only transient, occurring during the course of catalysis. A number of enzymes require metal ions for their activity which form coordination one or more coordination bonds with the substrate.